(19 August 2008)
P. 337: Restoring
function by the transdifferentiation of supporting cells of course
supposes that some supporting cells still remain in the damaged
sensory epithelium. If however the epithelium is allowed to degenerate
further, so that all the supporting cells are lost, then there is no
transdifferentiation, and no restoration of function (Izumikawa
et al., 2008). Since many severely deaf human
being are likely to have severely degenerated organs of Corti,
this is likely to limit the potential usefulness of the approach. (19
Izumikawa M, et al. (2008)
Response of the flat cochlear epithelium to forced expression of Atoh1.
Hear Res. 240:52-56.
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