Chapter 10

Notes (19 August 2008) 

P. 337: Restoring function by the transdifferentiation of supporting cells of course supposes that some supporting cells still remain in the damaged sensory epithelium. If however the epithelium is allowed to degenerate further, so that all the supporting cells are lost, then there is no transdifferentiation, and no restoration of function (Izumikawa et al., 2008). Since many severely deaf human being are likely to have severely degenerated organs of Corti,  this is likely to limit the potential usefulness of the approach. (19 August 2008)

Izumikawa M, et al. (2008) Response of the flat cochlear epithelium to forced expression of Atoh1. Hear Res. 240:52-56.

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